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Another indole reported in the mid-90s 7-hydroxymitragynine C23H30N2O5 is present in much lesser amounts 2% of total alkaloids but with the most potent opioid agonist and analgesic effect. On animal studies the kratom therapy review analgesic activity is reported to be 10x – 17x that of morphine. Other potency comparisons with morphine is from 6x orally with better oral absorption and 2x subcutaneously. Another analogue 9-hydroxycorynantheidine a 9-dimethyl analogue of mitragynine showed a partial agonist effect on opioid receptors in guinea-pig ileum. Alkaloidal extracts of leaves have showed very potent anti-inflammatory analgesic and opioid properties. Of the major alkaloids mitragynine is a stimulant and 7-hydroxymitragynine is sedative and analgesic acting primarily as an agonist at the
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u-opioid receptor. Mitragynine showed opioid-activity in animals.